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You should contact your GP if you experience: Unilateral (one-sided) breast swelling or a hard, irregular lump Nipple discharge, skin changes, or nipple inversion Rapidly progressive breast enlargement Associated symptoms such as testicular pain or swelling Breast changes alongside unexplained weight loss or fatigue In line with NICE guideline NG12 (Suspected Cancer: Recognition and Referral), GPs should consider an urgent two-week wait referral to a breast clinic for any male with a unilateral, firm, subareolar mass with or without nipple discharge, or any other breast presentation that raises clinical concern irrespective of age