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Nevertheless, the currently available evidence remains indirect and is insufficient to directly demonstrate either a synergistic antitumor effect of GLP-1/GCG co-agonism or an antitumor effect mediated through GCGR activation alone

Given the metabolic benefits of GLP-1RAs, caution is advised in patients with a history of depression or psychiatric vulnerability and a heightened vigilance for these events is warranted

Unfortunately, cash-paying patients typically dont benefit from these rebates

Study findings The current study included 351,913 adult patients with an average age of 65.3 years, with nearly equal representation of male and female patients