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Although proteomic changes induced by GLP-1GIPLani were less robust in the hypothalamus relative to hindbrain, GLP-1GIPLani more robustly induced POMC neuronal activity compared with GLP-1GIP, as assessed in vivo using fibre-photometric assessment of POMC neuronal activity in Pomc-cre mice, and ex vivo using whole-cell patch recordings in Pomc -GFP mice (Fig

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Other side effects are rare but may include: constipation, stomach pain, headache, fatigue, indigestion, dizziness, abdominal distension, belching, gas build-up, and low blood sugar in patients with Type 2 diabetes