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Route of administration matters because peptides face two chemical obstacles: degradation before they reach the target, and inability to cross biological barriers

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Journal of the American Heart Association, 14(5), e041369

These alterations were accompanied by increased expression of Cas-3 and NF-B, elevated levels of pro-inflammatory cytokines (TNF-, IL-6), and significant oxidative stress, as evidenced by increased MDA and decreased antioxidant enzyme levels (SOD, CAT, GSH-Px)