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doi: 10.1111/j.1939-1676.2003.tb02456.x

These cytokines are mechanistically relevant, as activating the TNF- signaling pathway leads to hypertension, atherogenesis, vascular dysfunction, and unfavorable cardiac remodeling following MI [48], while IFN- contributes to the progression of atherosclerotic CVDs through the JAK/STAT pathway [49]

However, long-term safety data including cardiovascular outcomes, heart-rate effects, and optimal dosing are still being gathered in Phase 3 studies, and no definitive safety conclusions can be drawn at this stage

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