LegitScript expects to see problematic behavior including illicit compounding, especially from overseas manufacturers, and counterfeit versions of brand name drugs for sale
Drug class Thiazide diuretic Mechanism of action Inhibits Na/Cl symporter in the distal convoluted tubule of the kidney Excretion of sodium and water blood volume blood pressure excretion of potassium, magnesium excretion of calcium (can help prevent kidney stones) Clinical uses Hypertension (first-line therapy) Edema (heart failure, nephrotic syndrome, cirrhosis) Prevention of calcium kidney stones Pharmacokinetics Well absorbed orally Renally excreted unchanged Not a prodrug Adverse effects Hypokalemia Hyponatremia Hyperuricemia gout Hyperglycemia (mild) Hypotension Hypercalcemia Contraindications / Caution Severe renal impairment Hypersensitivity to sulfonamides Hydrochlorothiazide = Active drug Chlorthalidone = Active drug Metolazone = Active drug Thiazide diuretics work directly
The ideal choices share several characteristics: they promote muscle preservation during caloric deficit, they enhance rather than impair fat oxidation, they produce minimal water retention, and they have manageable side effect profiles when used responsibly
Walking 20-30 minutes daily, light resistance training 2-3 times weekly, and avoiding intense exercise on injection days represents a reasonable approach
