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These can be quite severe

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This improvement of oxygen delivery and nutrient perfusion is relevant to the conversation as theres significant overlap between loose skin and poorly vascularized skin

166,167 The pathophysiology of diabetic mononeuropathy includes ischemic mechanisms, such as the occlusion of the vasa nervorum leading to nerve infarction, metabolic factors, including hyperglycemia-induced oxidative stress, and the formation of advanced glycation end products, contributing to nerve damage