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Hood S, Amir S

Fasting from dawn to sunset for four weeks also induced an anti-diabetes proteome response by upregulating the key regulatory proteins of insulin signaling at the end of 4th week during 4-week intermittent fasting (VPS8, POLRMT, IGFBP-5) and 1 week after 4-week intermittent fasting (PRKCSH), and an anti-aging proteome response by upregulating H2B histone proteins 1 week after 4-week intermittent fasting

The starting dose is 1.5mg, gradually increasing to 4mg, 9mg and 25mg, with patients required to remain on each dose level for at least a month before progressing

Dinner: Black bean soup with a side salad