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In colorectal cancer, IGF-2 secreted by cancer-associated fibroblasts binds to IGF-1R on cancer cells to activate the PI3K/AKT/mTOR and Hippo-YAP1 signaling pathways to promote cancer cell proliferation, migration and invasion

The primary analysis included 66,102 participants, and a sub-group analysis focused on 3,313 individuals who were newly initiated on either GLP-1 RAs or insulin as second-line treatment

Minimal Side Effects and Lowered Dependency on Medications Reduced reliance on medications: With lasting pain relief and reduced inflammation, patients may find themselves less dependent on painkillers and anti-inflammatory drugs

Science 129 , 569570 (1959)