what are semaglutide Understanding (GLP-1 RA): they the right choice for weight loss? GLP-1 Side Effects and Semaglutide:

Structural modifications allow them to stay in circulation for hours or even days: IGF-1 LR3 : 2030 hour half-life CJC-1295 with DAC : 58 day half-life PEG-MGF : detectable for up to 12 weeks Pharmacokinetic enhancements such as PEGylation or fatty acid acylation extend the peptides residence time, reduce renal clearance, and improve therapeutic utility. Veronese & Mero, BioDrugs What Determines How Long Peptides Stay in Your System

10.3748/wjg.15.2887 World J

Phase 2: Usually (but not always) a larger group of people (100 to 300) receive the treatment to further assess how effective it is, as well as its safety and side effects

Choosing between semaglutide and tirzepatide isnt about picking the stronger medication