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WZ: Supervision, Validation, Writing original draft

In experimental models, diabetes reduces NGF expression in target tissues including skin and muscle, impairing retrograde transport to neuronal cell bodies and decreasing neuropeptides such as substance P and calcitonin gene-related peptide [146]

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CRs potential as a treatment for mental health disorders, combined with its ability to induce epigenetic modifications, is particularly relevant given that aberrant epigenetic changes contribute to the pathophysiology of mental health disorders and addiction (165168)

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