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In IBD, depletion of SCFA-producing bacteriaparticularly butyrate producerscorrelates with increased neutrophil infiltration and NET formation, thereby accelerating disease progression (90)

Although drug injections have been administered in a similar manner for a long time, the guideline for drug injection has been continuously updated based on clinical trials for better treatment with overcoming technical limitations 1, 2, 6,7,8,9