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Serious side effects of semaglutide may include acute pancreatitis, kidney or gallbladder problems, an allergic reaction to the drug, pulmonary aspiration during surgery, or vision changes (in people with type 2 diabetes)

For patients using semaglutide with other diabetes medications, dose adjustments of sulfonylureas or insulin may be necessary to prevent hypoglycemia and reduce overall medication burden that might contribute to side effects