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(4) E + S ES (5) ES = E + P Why the substrate S would be bound selectively into the enzymes active site is explained in terms of the well-known lock and key principle (and its updated induced-fit modification) [Kent, 2000]

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, in efflux from cancer cells as the cause for their chemo-resistance) and in the mechanisms responsible for the dose-limiting kidney toxicity of cisplatin and for its years-long terminal half life [63,64,65]

Replenishing glutathione helps counteract these underlying changes, giving patients a clearer, more energized, and healthier baseline to work from