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Furthermore, trials that did not include T2D subjects, lacked a placebo control, were not designed as randomized controlled trials, did not assess SGLT-2 inhibitors or GLP-1 receptor agonists, or employed combinative antidiabetic therapies were also omitted from this analysis.The primary endpoint for this study was major cardiovascular episodes (MACE), which was defined as cardiovascular death, myocardial infarction or stroke

Most users notice visible results in 48 weeks with consistent use

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