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A value of p 1.0 was defined as antagonism) for all concentration gradients, indicating a synergistic interaction between the oridonin and liposome-MAL

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This transporter can also mediate uptake of oxidized VitC (dehydroascorbic acid, DHA) which is reduced back after uptake by the cell, resulting in depletion of intracellular antioxidants such as glutathione (GSH), nicotinamide adenine dinucleotide phosphate (NAPDH) and SOD enzymes, thereby further increasing reactive oxygen species (ROS) levels in cancer cells [32]