In early human clinical studies, CJC-1295 produced sustained, dose-dependent increases in both growth hormone and IGF-1 levels

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Indicative of the innovation that exists within the pipeline, more than thirty mechanisms of action are represented by the ~33% of drug candidates with mechanism of action classified as "Other", (Figure 3 c)
This contraindication stems from observations in rodent studies where semaglutide and other GLP-1 receptor agonists caused dose-dependent and treatment-duration-dependent thyroid C-cell tumors