Subjective evaluations Skin whitening and smoothening at the test site and improvement in fine lines were evaluated subjectively by the investigator and by the subjects in accordance with the following scoring pattern: 3= marked deterioration 2= moderate, visibly uneven deterioration 1= slight deterioration 0= no perceptible change or improvement 1= slight change or improvement 2= moderate change or improvement (whitening
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the present invention solves these problems by providing BPC peptide salts and a pharmaceutical or diagnostic composition comprising a pharmaceutically or diagnostically effective amount of the salts of BPC peptides said peptides being constituted of 8 to 15 amino acids, wherein the anion of the salt is a negatively charged peptide comprising 8 amino acid residues having the general formula (I) wherein Xaa is a neutral aliphatic amino acid residue, in particular Ala, bAla, Leu, Ile, Gly, Val, Nle or Nva, Yaa is a basic amino acid residue, in particular Lys, Arg, Orn or His and Zaa is an acidic amino acid residue, in particular Glu, Asp, Aad or Apm and wherein the cation of the salt is the cation of an inorganic or organic nontoxic and pharmaceutically acceptable base

Komives presented a comprehensive review discussing the utility of HDX-MS in discovery of IDRs in proteins, monitoring coupled folding and binding, and characterization of protein aggregates and oligomers ( 2.13.2 Ion mobility-mass spectrometry (IM-MS) Ion mobility-mass spectrometry (IM-MS) is an analytical technique that separates ions based on their collision cross-section (CCS, which is a measure of the size and shape of ion that defines its collision rate) in the gas phase