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According to the FDA's press release it agreed to approve the drug for obesity based on three randomised, double-blind, placebo-controlled trials during which more than 2,600 patients received Wegovy for up to 68 weeks and more than 1,500 patients received placebo (US FDA 2021)

According to Vocca, when initiating a fiber supplement, you should start with the minimum dose and increase your daily fiber intake by only 5 g per week

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If you experience persistent nausea, vomiting, or severe bloating after starting semaglutideespecially in the first 4 weekseliminating caffeine for 710 days serves as a diagnostic tool to isolate medication effects