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To facilitate inter-mice statistics, each rs-fMRI image was spatially smoothed (0.5 mm isotropic Gaussian kernel), and each voxels time series was bandpass filtered from 0.01 to 0.3 Hz [40, 41]

2 Methodology This review was conducted through a literature search in PubMed, Scopus, Web of Science and Google Scholar, using combinations of keywords such as Parkinsons disease, -synuclein aggregation, sirtuins, insulin signaling, GLP-1 and incretin mimetics phytomolecules, neuroprotection, and therapeutics. The search covered publications from 2010 to January 2026