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Other potential gastrointestinal side effects of semaglutide can include the following: Eructation (belching or burping) Decreased appetite Abdominal distension Dyspepsia (indigestion) Flatulence (gas) Gastritis (inflammation of the stomach lining) Most patients will experience at least one side effect, but these effects are generally minimal if the dosing is gradual and appropriate, says Jessica Marren, APRN, CRNA, the owner, CEO, and lead injector at Bella Bar Medspa in Brownsville, Texas

Studies have shown that it performs better than other anti obesity medications by producing significant satiety even after small meals at low dosages when combined with lifestyle changes such as eating healthy, dieting, and regular exercise

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These risks are theoretical, not documented in human trials, but they are reasons community references include cycle off-periods