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BBR was described as a potential antitumor agent that induces cell cycle arrest in G0/G1 phase, increases Cip/p21 and Kip/p27 protein expression, decreases expression of cyclin D1, D2, and DE, and the cyclin-dependent kinases Cdk2, Cdk4, and Cdk6, promoting apoptosis in HL-60 human leukemia cells (Li et al., 2017)

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2017 meta-analysis: Five RCTs in 631 adults with insulin resistance showed that 23 g/day L-carnitine for 4 weeks to 12 months improved insulin resistance, with benefits at 12 months exceeding those at 3 months [3][42]