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Activation of AMPK with concurrent mTOR inhibition dampens NLRP3 inflammasome activity, limits IL-1mediated pyroptosis, and restores autophagic flux, effects abolished when AMPK is inhibited (Yang et al., 2019

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Ask About Dose Adjustment If rhodiola is providing meaningful benefit (documented fatigue reduction, stress management) and your prescriber agrees it is worth continuing, one option is a modest amlodipine dose reduction from 10 mg to 5 mg with careful BP monitoring during the transition

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