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The authors hypothesized that Astragalus polysaccharide (APS) may exert protective and antidepressant effects on the hippocampus by inhibiting CMUS-induced oxidative stress, which is achieved through APS activation of the Nrf2-ARE pathway in depressed rats (Su et al., 2021)

One example is the dysregulation of GSH homeostasis and alterated levels or functions of GSTs (both decrease or increase) 48,49

This finding indicates that the effects of dopamine on astrocytes, like many other cell types, is context- and environment-dependent