glp-1 ibd GLPs as novel therapeutic options in IBD-potential mechanisms of action Relevance of Glucagon-Like Peptide 1

BMJ Case Rep 2022;15(7)

Human studies have been more limited

Upon activation of the GLP-1 receptor, cAMP levels increase, which activates the cAMP response element-binding protein (CREB) (Bomba et al., 2018), This in turn induces the expression of brain-derived neurotrophic factor (BDNF), a critical neurotrophic factor that acts via its receptor, tropomyosin-related kinase B (TrkB)

These findings emphasize that targeted antagonism of NMDA receptor signalling lowers body weight independently of MC4R, indicating that this preclinical drug candidate might not only be effective in treating polygenic obesity but also holds potential as an effective weight loss strategy for patients with loss-of-function mutations in MC4R , the most common form of monogenic obesity 32