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The PDUFA date is not a guaranteed approval date the FDA can approve, issue a Complete Response Letter requesting more data, or extend the review

Ever since getting back on a GLP-1 (Zepbound) in November for the third time, her symptoms have been totally under control

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In fact, this study shows that the levels of these molecules are significantly lower in joint fluid than in the blood/plasma and may be incidental to the function of the joints. Jeffrey Zarin, MD Also, there did not seem to be a difference between patients that had arthritis and those that did not, so conclusions about the effect of GLP-1 on arthritis should also be interpreted cautiously, Zarin added