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Furthermore, lactate accumulation in these models is LDHA-dependent, as genetic deletion or pharmacological inhibition of LDHA has been shown to mitigate vascular remodeling and right ventricular dysfunction in multiple PH models, including SU5416/hypoxia-induced mouse models, monocrotaline-induced rat models, and chronic hypoxia-induced mouse models

10.1016/j.joca.2019.08.007 125 YaoH.XuJ.WangJ.ZhangY.ZhengN.YueJ.et al (2021)

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