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Furthermore, PC1/3 colocalization with glucagon was elevated in liraglutide-treated WT mice compared with that in liraglutide-treated KO mice (Figure 1, D and E

To corroborate these findings on a functional level, we isolated activated ILC2s from IL-33 challenged BALB/c mice ( Figure 3A ), which were then incubated for 24h with either an MT1 agonist (Ramelteon), MT1 antagonist (S-26131), MT2 agonist (Tasimelteon), MT2 antagonist (4-P-PDOT) and/or melatonin ( Figures 3BE )