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However, the normal utilization and release of iron are constrained, resulting in elevated production of ROS and a decrease in the biosynthesis of heme and Fe-S clusters during conditions of iron overload [57]

Acknowledgements This investigation was funded in part by the National Institutes of Health through grants R01 NS055095 (RAG) and in a facility constructed with support from Research Facilities Improvement Program Grant C06 RR15482 from the National Center for Research Resources, NIH

However, symptoms are far more likely to be related to underlying conditions that cause B12 elevationsuch as liver disease, kidney dysfunction, or haematological disordersrather than the elevated B12 itself

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