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2.4 Combining DPI, MitoQ and vincristine induces cell death of MNA NB cells To characterize the interaction between MitoQ, DPI, and vincristine, we assessed their effects on cell death at IC50/2 and IC50/3 concentrations in four NB cell lines: Be(2)-C (MNA), IMR-32 (MNA), IMR-5/75 (MNA with MYCN downregulatable), and SH-SY5Y/MYCN (non-MNA, MYCN-inducible)

Figure 3 Beyond the inflammatory response, choline metabolism is also implicated in IL-4-induced macrophage polarization, critical for immunity against intestinal helminth infection, resolution of inflammation, and tissue repair

10.1016/j.molmed.2021.12.007 101 LuH.XiaoH.DaiM.XueY.ZhaoR

Initial results from studies in rodents suggested a synergistic role of dual GLP-1 and glucagon agonism on reducing food intake and led to the development of numerous unimolecular GLP-1/glucagon co-agonists