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Mazdutide is approved in China with strong Phase 3 data (20.1% weight loss) and a differentiated glucagon component that may offer unique advantages for hepatic fat reduction and energy expenditure

Non-targeted lipidomicssample preparation The liver, brain, kidney, lung, and adipose tissue were homogenized with a pre-chilled BioPulverizer (59012MS, BioSpec) and then placed on dry ice

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Arachidonic acid is primarily metabolized via two pathways: the cyclooxygenase (COX) pathway and the lipoxygenase (LOX) pathway