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(Environmental (Exogenous) Factors and Endogenous Factors) is mandatory for the development of GD ( The biological action of autoantibodies against TSHR was the reason for their discovery by Adams and Purves ( Anti-TSHR antibodies are found in 90% of GD patients, 020% HT, and 1075% of atrophic thyroiditis patients ( Thyroid Peroxidase Thyroid peroxidase is a poorly glycosylated membrane-bound enzyme, responsible for iodine (I 2 ) oxidation and iodination of tyrosyl residues of the Tg molecule (29)

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