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For patients with poor glycemic control who stop GLP-1, monitor glucose closely and use short-acting insulin protocols to avoid hyperglycemia

The molecule consists of 39 amino acids, with the non-natural AIB incorporated at positions 2 and 13, which make it difficult to make using cheaper recombinant technologies

These locations were selected because they provide adequate subcutaneous tissue depth for reliable absorption, easy access for self-administration, and relatively low risk of hitting blood vessels or nerves