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In humans, upon detecting oxidative stress, the NRF2 partner KEAP1 no longer ubiquitin-labels NRF2 for degradation, resulting in NRF2 stabilization and activation of NRF2-response genes

In terms of immunomodulation, butyrate enhances interleukin-10(IL-10) secretion by regulatory B cells (B10) and promotes regulatory T cells (Treg) differentiation through HDAC inhibition, while simultaneously suppressing inflammatory responses (79)

#PharmaNews #IndianPharma #PharmaUpdates #PharmaStrategy #PharmawithHJ #HJ To view or add a comment, sign in Granules India Limited has secured Sole First-to-File (FTF) status from the US Food and Drug Administration (USFDA) for its Abbreviated New Drug Application (ANDA) for Sodium Oxybate Extended-Release for Oral Suspension, the generic version of LUMRYZ extended-release oral suspension

P = .001)