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Perilipin-null mice also display a significant resistance to diet-induced obesity (78, 106, 127) that is explained, at least in part, by increased beta-oxidation of fatty acids, the products of lipolysis (106), following from a compensatory induction of genes involved in lipid and energy metabolism and a downregulation of genes involved in lipid biosynthesis (20)

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Cohort 2 (from June 2026) covers BMI 35 to 39.9 with four or more conditions

March 2022 Introduction Demographics Causes Clinical features Variation in skin types Complications Diagnosis Differential diagnoses Treatment Outcome What is keratosis pilaris