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A systematic review of the safety of lisdexamfetamine dimesylate in adult patients with attention-deficit hyperactivity disorder

4.2 The PUF Hub Although the complete loss of the GSC pool in adult fbf-1 fbf-2 double mutants highlights that these two genes function redundantly to promote GSC proliferation, the loss of the GSC pool was reminiscent, but still distinct, from that of a loss of GLP-1/Notch signaling

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Laboratory investigations have explored its interactions with hypothalamic and limbic receptor systems, as well as its potential modulatory effects on stress hormone pathways in preclinical settings