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Tirzepatide was initially approved by the FDA for type 2 diabetes and later received approval for chronic weight management in adults with obesity or overweight plus at least one weight-related condition

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Its most distinctive physicochemical property is hydrolytic stability at low pH, unlike almost every peptide of comparable length, BPC-157 resists degradation in human gastric juice, a characteristic emphasised throughout the published work of Sikiric and colleagues (Curr Med Chem, 2012)

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