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The Uox KO mouse is widely recognized as a "gold standard" disease model that closely mirrors human uric acid metabolism, providing an indispensable in vivo environment for evaluating cutting-edge urate-lowering therapies [6-7]

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Among these, liraglutide in the LEADER study, semaglutide in the SUSTAIN-6, albiglutide in the Harmony Outcomes, dulaglutide in the REWIND, and efpeglenatide in the AMPLITUDE-O exhibited significant beneficial effects on 3-point major adverse cardiac events (3P-MACE: death from CV disease, non-fatal myocardial infarction, and non-fatal stroke), the primary end point of each study, compared to the placebo group, respectively

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