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The OFA argued that the FDAs removal of tirzepatide, the active ingredient in these drugs, from its shortage list would limit access to essential treatments and increase drug prices

Using two independent bioinformatic tools 29,30 , we found a significant overlap with transcripts associated with genetic susceptibility to obesity in humans, suggesting that GLP-1MK-801 targets biological pathways implicated in common polygenic forms of human obesity 1,31 (Fig