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Description

Even if they get to the epithelium, they tend to have poor permeability, usually resulting in less than 1 percent bioavailability (the proportion of a drug that enters the circulatory system when introduced into the body, thereby having an active effect)

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Meaning even optimal HGH secretion won't translate to tissue-level effects if the cellular environment can't respond

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Although the primary motor outcome was neutral, the study confirmed safety and hinted at benefits in secondary domains, solidifying GLP-1 RAs as a viable therapeutic avenue

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