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Large epidemiological data demonstrate that CKM multimorbidity affects up to 40% of adults in developed countries and accounts for a substantial proportion of global cardiovascular deaths

Some patients report slightly less nausea with oral semaglutide, though both forms achieve the same therapeutic effect

However, there is growing pressure from patients and healthcare professionals in various fields to use these drugs beyond approved indications to achieve benefits across multiple organ systemscardiovascular, musculoskeletaland to obtain anti-inflammatory effects

Microglia constitute the first line of immune defense