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In contrast, a large meta-analysis, including 12 cohorts from the Psychiatric Genomics Consortium, Generation Scotland: The Scottish Family Health Study, and UK Biobank, found statistically significant associations between T2DM PRS and MDD, particularly in cases of early onset [68]

Moreover, exogenous administration of acrolein into rodent spinal cord also induced pain symptomatology, whereas the treatment with its scavenger hydralazine modestly diminished sensitivity to both tactile and thermal stimuli

Wang H, Ye X, Zhang Y, Ling S

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