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10.1126/science.aab3389 19 BlackburnE

Important considerations include: Potential interactions with hormonal contraceptives (particularly with tirzepatide and exenatide) Pregnancy planning (GLP-1 medications require discontinuation before conceptiontypically 2 months for semaglutide and 1 month for tirzepatide) Management of gastrointestinal side effects that might overlap with endometriosis symptoms Some hormonal therapies for endometriosis can affect weight, and addressing metabolic health may be a separate but important consideration

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What separates semaglutide from tirzepatide in a prescriber's decision