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Further studies are needed to determine whether other factors may also be involved

No, B12 injections are licensed medicines used to treat confirmed vitamin B12 deficiency, whilst lipotropic injections are unlicensed combinations marketed for weight loss without robust clinical evidence

In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)

Accepted 17 March 2022