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Within these populations are people with risk factors that might make them better candidates than others, such as: Stress: Chronic stress not only promotes an inflammatory state but also can prolong bacterial infections and discourage wound closure.7 21 22 Overweight or obesity: People with excess weight are also at risk for chronic inflammation, persistent infections, and slower wound healing

Notably, apoptosis is triggered in response to DNA damage resulting in nuclear p53 activation and consequent upregulation of pro-apoptotic proteins and their translocation to mitochondria to trigger the MOMP-mediated pathway

doi: 10.1093/ije/dyaa216

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