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Rather than relying solely on appetite suppression and glycemic control, practitioners are exploring strategies that optimize fat metabolism, preserve lean mass, and support overall metabolic health
In these first short-term clinical trials, focused on safety and dose optimisation, the administration of two different GLP-1R/GcgR co-agonists reduced HbA 1c in overweight diabetic individuals, with some degree of body weight loss [69]
Its triple-receptor action may provide more comprehensive effects than single-target medications
Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day
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