In the UK, such products are regulated under the GB Cosmetic Products Regulation (retained from EU Regulation 1223/2009, overseen by the Office for Product Safety and Standards, OPSS)
In a study comparing 42 patients with FIC1 disease to 60 patients with BSEP disorder, PFIC1 patients suffered from symptoms like diarrhoea, allograft steatosis, and pancreatic disease and were less likely than BSEP disease patients to catch up with weight gain following LT [55]
40 l of supernatant was removed from each treated well and transferred into a 96-well clear bottom black microplate (Costar, Corning, USA)
Galipeau J, Benaim E, Spencer HT, Blakley RL, Sorrentino BP