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However, the effects on the gastrointestinal system are widespread

No medication GLP-1 or otherwise is a cure for lipedema

Higher is not always better: 9 mg often delivers a better efficacy-to-tolerability ratio than 12 mg

Around the same time, I think you remember that all of pharma was interested in obesity in the early 90s, everyone wanted to do diabetes as well as obesity, but they were separate teams and they all wanted to do small molecules, but it just happens to be so that the best idea we could find at that time was actually GLP-1, because we actually had clinical data relatively early that GLP-1 was a really good candidate as a treatment for diabetes because of the glucose sensitivity of the actions