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In clinical trials, retatrutide is being examined for its ability to assist with obesity, type 2 diabetes, metabolic dysfunction-associated steatohepatitis (MASH), chronic kidney disease, and cardiovascular risk reduction

The direct administration of microbiota-derived metabolites, such as short-chain fatty acids (SCFAs) and indole derivatives, has been shown in experimental models to improve insulin sensitivity, reduce inflammation, and promote gut hormone secretion, potentially bypassing the need for sustained microbial engraftment (112)

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Epub 2017 Mar 6