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In osteoarthritis conditions, preclinical models highlight direct anti-catabolic and immunomodulatory actions (e.g., liraglutide reduces IL-6, MMP-3) [45]

However, WADA prohibits intravenous infusions or injections exceeding the permitted volume threshold within a 12-hour period, except during legitimate hospital treatment, surgical procedures or clinical diagnostic investigations

Specifically, KLF2 activates thrombomodulin, reduces plasminogen activator inhibitor (PAI)-1 expression and inhibits the cytokine-driven TF expression, ultimately preventing or prolonging clotting time under basal or inflammatory conditions [81,82,83] (Fig